Cellular Responses to the DNA Damaging Natural Compound Leinamycin
نویسندگان
چکیده
منابع مشابه
Cellular responses to DNA damage.
For many years, the study of the regulation of the SOS network was complicated by both the complexities of the responses and the interrelationships of the key regulatory elements. However, recently the application of powerful genetic and molecular biological techniques has allowed us to gain a detailed picture of the regulation of this complex network. The network is now known to consist of mor...
متن کاملCellular responses to DNA damage.
Cells are constantly under threat from the cytotoxic and mutagenic effects of DNA damaging agents. These agents can either be exogenous or formed within cells. Environmental DNA-damaging agents include UV light and ionizing radiation, as well as a variety of chemicals encountered in foodstuffs, or as air- and water-borne agents. Endogenous damaging agents include methylating species and the rea...
متن کاملSequence specificity of DNA alkylation by the antitumor natural product leinamycin.
Reaction with thiol converts the antitumor natural product leinamycin to an episulfonium ion that alkylates the N(7)-position of guanine residues in double-stranded DNA. The sequence specificity for DNA alkylation by this structurally novel compound has not previously been examined. It is reported here that leinamycin shows significant (>10-fold) preferences for alkylation at the 5'-G in 5'-GG ...
متن کاملCellular Responses to Cisplatin-Induced DNA Damage
Cisplatin is one of the most effective anticancer agents widely used in the treatment of solid tumors. It is generally considered as a cytotoxic drug which kills cancer cells by damaging DNA and inhibiting DNA synthesis. How cells respond to cisplatin-induced DNA damage plays a critical role in deciding cisplatin sensitivity. Cisplatin-induced DNA damage activates various signaling pathways to ...
متن کاملThiol-independent DNA alkylation by leinamycin.
Covalent modification of cellular DNA can have profound biological consequences and, therefore, the mechanisms by which small organic molecules react with DNA are of interest in both medicinal chemistry and toxicology.1-6 The reactions underlying the biological activity of DNA-damaging agents are diverse and chemically interesting.1 Some agents contain functional groups that are inherently reac...
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ژورنال
عنوان ژورنال: Journal of Cancer Science & Therapy
سال: 2013
ISSN: 1948-5956
DOI: 10.4172/1948-5956.s8-003